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KMID : 0358420050480030701
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Korean Journal of Obstetrics and Gynecology
2005 Volume.48 No. 3 p.701 ~ p.708
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The expression of epidermal growth factor and fibroblast growth factor-2 in the eutopic endometrium of women with endometriosis
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최정원/Choi JW
이향아/이사라/홍석호/나희영/이영진/김성훈/채희동/김정훈/강병문/Lee HA/Lee SR/Hong SH/Na HY/Lee YJ/Kim SH/Chae HD/Kim CH/Kang BM
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Abstract
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Objective: To compare the expression of epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF-2) in the eutopic endometrium of women with and without endometriosis.
Methods: Thirty-two women with histologically confirmed endometriosis after laparotomy or laparoscopy were recruited. Twenty-eight women with carcinoma in situ of the uterine cervix, uterine myoma and ovarian tumor but no evidence of endometriosis served as control. Following isolation of total RNA from endometrial tissue and reverse transcription, cDNA samples were amplified by real time PCR to quantify the expression of EGF, FGF-2, and GAPDH genes.
Results: Including all menstrual phases, the levels of mRNA expressions of EGF and FGF-2 were not different between the eutopic endometrium of women with and without endometriosis. When analyzed separately according to the 6 menstrual phases, no differences were found between the two groups, either.
Conclusion: This study shows that the levels of mRNA expressions of EGF and FGF-2 in the eutopic endometrium were not different between women with and without endometriosis.
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